Publications

Publications

(* Corresponding author)

  •  “Three-Dimensional Visualization of Kinase Inhibitors as Therapeutically Relevant Examples To Reinforce Types of Enzyme Inhibitors” Kurup, S.*; Sakharkar, P. Journal of Chemical Education  2019
  • “The journey of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) from lab to clinic.” Namasivayam, V.; Vanangamudi, M.; Kramer, V. G.; Kurup, S.; Zhan, P.; Liu, X.; Kongsted, J.; Byrareddy, S.N. J. Med. Chem. 2018
  •  “Synthesis and biological activity of N4-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines as dual inhibitors of aurora kinase A and epidermal growth factor receptor kinase.” Kurup, S.*; McCallister, B.; Liskova, P.; Mistry, T.; Fanizzi, A.; Stanford, D.; Keller, U.; Hoellein, A. Journal of Enzyme Inhibition and Medicinal Chemistry 2018, 1, 74-84.
  • “Three-dimensional visualization of kinase inhibitors as therapeutically relevant examples to reinforce varied types of enzyme inhibition” Kurup, S.*; Sakharkar, P. J. Chem. Educ. (ed-2017-00821p under review, manuscript submitted October 2017)
  •  “A team-based assignment to integrate basic science and pharmacotherapeutic principles for anticancer agents.” Kurup, S.*; Jungsuwadee, P.; Sakharkar, P.  Am. J. Pharm. Educ. 2017, 81, Article 93.
  • “Kinase inhibition as a therapeutic approach for P. falciparum malaria” Kurup, S.* Malar Cont Elimination 2015, 4, e131.
  •  “Synthesis of 5,7-disubstituted-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amines as microtubule inhibitors.” Gangjee, A.; Kurup, S.; Smith, C.D.  Bioorg. Med. Chem. 2013, 21, 1180-9.
  •  Kurup, S.; Dineley, K.; Malaiyandi, L.; Adewuya, R.; Potempa, L.A. “Drugs to Treat Head and Neck Cancers: Mechanisms of Action.” Book chapter In Head & Neck Cancer: Current Perspectives, Advances, and Challenges; Radosevich, J.A., Ed.; Springer: Dordrecht, 2013:pp 861-913.
  •  “N4-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors.” Gangjee, A.; Kurup, S.; Ihnat, M.; Thorpe, J.; Disch, B.  Bioorg. Med. Chem. 2012, 20, 910-14.
  • “Synthesis and biological activity of N4-phenylsubstituted-6-(2,4-dichlorophenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular    endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents.” Gangjee, A.; Kurup, S.; Ihnat, M.; Thorpe, J.; Shenoy, S.  Bioorg. Med. Chem. 2010, 18, 3575-87.
  • “Recent Advances in Classical and Non classical Antifolates as Antitumor and Antiopportunistic Infection Agents: Part II.” Gangjee, A.; Jain, H.; Kurup, S.  Anticancer Agents Med. Chem. 2008, 8, 205-231.
  • “Recent Advances in Classical and Non classical Antifolates as Antitumor and Antiopportunistic Infection Agents: Part I.” Gangjee, A.; Jain, H.; Kurup, S.   Anticancer Agents Med. Chem. 2007, 7, 524-542.
  • “Dihydrofolate Reductase as a Target for Chemotherapy in Parasites.” Gangjee, A.; Kurup, S.; Namjoshi, O.” Curr. Pharm. Des. 2007, 13, 609-639.
  • “Trends in male contraception.” Kurup, S.; Poddar, S. Indian Journal of Pharmaceutical Education 2002, 36, 176-183.

 

Selected Conference Proceedings

(* Corresponding author)

  • “A systematic review of randomized clinical trials for therapeutic outcomes of anti-EGFR agents used in combination with other targeted therapies” Kurup, S*.; Liskova, P.; Jungsuwadee, P.; Sakharkar, P.; Chandrasekhara, S. Poster presentation at the 111th American Association for Cancer Research (AACR) Annual Meeting, Chicago,IL, 2018 (#589).
  •  “Design, synthesis, selection, and evaluation of a potent multi-kinase targeting N4-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amine derivative with significant anticancer activity in P53 mutant and wild type models of upper GI cancers,” Samant, A.; Visal, T.; Pancholi, P.; Bapat, S.; Kansara, D.; Dichwalkar, T.; Senones, R.; Kurup, S.; Sehdev, V. Poster presentation at the 111th American Association for Cancer Research (AACR) Annual Meeting, Chicago,IL, 2018 (#2800).
  •  “RS-41, a multi-targeted kinase inhibitor, induces cell cycle arrest and apoptosis in p53 mutant and wild type models of upper gastrointestinal cancers,” Visal, T.; Patel, S.; Pancholi, P.; Bapat, S.; Samant, A.; Kansara, D.; Kurup, S.; Sehdev, V. Poster presentation at the 110th American Association for Cancer Research (AACR) Annual Meeting, Washington, DC, 2017 (#4180).
  •  “Design, synthesis and biological evaluation of 4-substitutedanilinopyrrolo[2,3-d]pyrimidines as multi-targeted inhibitors of EGFR, JAK2 and AURKA” Kurup, S.*; McCallister, B.; Senones, R.; Mistry, T.; Zych, S.; Pancholi, P.; Bapat, S.; Fanizzi, A.; Stanford, D.; Sehdev, V. Abstract for poster presentation at the 35th National Medicinal Chemistry Symposium-American Chemical Society, Chicago, IL 2016 (#56).
  •  “Structure-Based Design of Dual inhibitors of HIV Integrase and Ribonuclease H” Kurup, S.*; Jacob, S.; Raghavan, S. Abstract for poster presentation at the 2nd International Conference on Retroviruses and Novel Drugs, Chicago, IL 2015 (#6).
  •  “Synthesis and biological activity of 4-substituted pyrrolo[2,3-d]pyrimidines as inhibitors of mitotic kinases” Kurup, S.*; McAllister, B.; Mistry, T. Abstract for poster presentation at the 45th American Chemical Society Central Regional Meeting, Pittsburgh, PA 2014 (CHEM 106).
  • “Identification of Small Molecule Substrate-Competitive Kinase Inhibitors” Santos, S.; Kurup, S.; Steffey, M.; Soellner, M. Abstract for poster presentation at the 245th American Chemical Society National Meeting, New Orleans, LA 2013 (MEDI 19).
  • “Using Molecular Modeling to Integrate Biochemistry and Medicinal Chemistry in a Pharmacy Curriculum” Kurup, S.*; Potempa, L. A. Poster presentation at the American Association of the Colleges of Pharmacy (AACP) Annual Meeting, Kissimmee, FL, July 14-18, 2012.
  • “A Team-Based Unknown Drug Project Linking Medicinal Chemistry, Pharmacology and Clinical Pharmacy”
Fuentes, D.G.; Benken, S.T.; Kurup, S. Poster presentation at the American Association of the Colleges of Pharmacy (AACP) Annual Meeting, Kissimmee, FL, July 14-18, 2012.